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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before
Once injected (usually once weekly), they mimic the effects of GLP-1, helping your body better control blood sugar and manage hunger
Free Radical Biology and Medicine , 67, 396-407
Who Should Not Take GLP-1 Medications
What Does the Research Say About GLP-1s and PMOS
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