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The combination of the restrictive diet and increased physical activity is also what makes weight loss so difficult as the more you work out, the more your appetite is likely to increase, and the more nutrients you will require in order to ensure that your body is getting all of the nutrients it requires in order to keep exercising and burning the stored fat

However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use

Additionally, these medications slow gastric emptying, prolonging the feeling of fullness after eating and reducing the frequency of hunger between meals

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no pharmaceutical company pursued FDA drug approval after the negative results