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Negative side effects may include a paradoxical decrease in energy levels (most likely due to detoxification from methylation) or slight pain at the injection site which diminishes over 5-10 days
This can affect daily activities and may be particularly challenging for RA patients, who may already experience fatigue due to their condition
This effect is linked to the expression of CD36, a cell surface protein known for its roles in lipid metabolism, including fatty acid and lipoprotein uptake, as well as its involvement in innate immunity and inflammation
Since July 2025, Wegovy has been the preferred GLP-1 medication on CVS Caremark formularies (Aetna's pharmacy benefit manager)
McGuire FP, et al
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