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Nearly half of the patients with HF are diagnosed with HF with preserved ejection fraction (HFpEF), a subclass of HF in which patients are more likely to be older and female, with multiple chronic comorbidities, such as hypertension, type 2 diabetes, and obesity (Owan et al., 2006

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Across this body of research, no significant toxicity has been reported at doses ranging from 1 g/kg to 10 mg/kg in rodent models