In a Macedonian population, the GPx1 Pro198Leu genotype showed an overall protective effect on prostate cancer risk, and erythrocyte GPx1 activities were significantly decreased in prostate cancer patients compared with controls [73]
Research has revealed that the complex modulates the expression of over 4,000 mammalian genes, with particularly pronounced effects on genes involved in tissue repair, antioxidant defense, and inflammatory resolution
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However, while ML-098 shows a preference for Rab7, it also interacts with several other members of the Ras GTPase superfamily, including Cdc42, Ras, Rab2a and Rac1, thus limiting its clinical use [74]