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GLP-1 receptor agonists and the dual agonist tirzepatide modulate appetite, satiety, and gastric emptying, with evidence from STEP (NEJM 2021), SURMOUNT (NEJM 2022), and SURMOUNT-OSA (NEJM 2024)

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Weight regain after bariatric surgery affects many patients within 25 years post-operatively, prompting growing interest in pharmacologic interventions

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