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Aldeghi, M., Heifetz, A., Bodkin, M

An endosome-enriched self RNA, Rmrp , initially brings TLR3 ectodomains into close proximity and keeps cytoplasmic TIR domains apart, acting as a ligand mimic by causing adoption of an inactive pre-dimerized conformation on the membrane instead of the monomeric form

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Per week: 14 swabs (2/day) 4 weeks: 56 swabs recommend 1 100-count box 6 weeks: 84 swabs recommend 1 100-count box 8 weeks: 112 swabs recommend 2 100-count boxes Protocol Overview Concise summary of the once-daily regimen