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From a strategic perspective, METRNL illustrates the limitations of purely receptor-centric approaches to peptide drug discovery
Liraglutide was used in patients with type 1 diabetes, whereas exenatide was use in patients with type 2 diabetes
2021, NEJM) for Wegovy or SURMOUNT-1 (Jastreboff et al
On the other side, Semaglutide injections are FDA-approved and clinically proven to aid weight loss, providing a higher success rate for individuals struggling with obesity or weight-related health concerns
This can depend on stage of disease, weight and pre-existing vascular conditions
Funding The author(s) declare that financial support was received for the research, authorship, and/or publication of this article
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