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Step 1: In this step, some enzymes (Cytochrome P450 enzymes) change estrogen into a slightly different form

In the context of ovarian cancer, Cutter et al

Although genetically different, this CD56 bright NK cell population shared many similarities with a unique subset of CD56 superbright CD16 - decidual NK cells (dNK) deprived of cytotoxic activity, but involved in the modulation of decidual vascular growth during pregnancy through the secretion of angiogenic factors, such as VEGF, PlGF, and IL-8 (108)

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As time elapsed, they identified three phases where different populations became dominant

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