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Additionally, seek advice if you notice confirmed hypoglycaemia (blood glucose below 4.0 mmol/L) on multiple occasions, particularly if you are not taking sulphonylureas or insulin, or if you experience symptoms of dehydration such as reduced urine output, dark urine, extreme thirst, or confusion

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Most patients find a medication and dose combination that controls appetite while keeping side effects minimal, often within the first 3-4 weeks of adjustments

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Preclinical studies have shown that venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake