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[10] Equivalent guidance for retatrutide will be established upon licensing
The high molecular homology of liraglutide to the native GLP-1(97% amino acid homology) with great protraction properties may explain the high prevalence of symptomatic cholelithiasis among liraglutide users (81.8%) than other GLP-1RAs [13, 14]
Tirzepatide adds GIP receptor activation for enhanced weight loss, and next-generation triple agonists are adding glucagon receptor activation to increase caloric burn
Additionally, TMAO induced hypertension by accelerating vascular endothelial dysfunction (124)
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Treatment selection should be individualized based on clinical priorities and patient characteristics
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