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Signals for disease modification Evidence for true disease modification remains low-certainty and hypothesis-generating, with recent observational signals serving as a foundation for potential disease modification rather than established therapeutic benefit (100)
Science 339 , 819823 (2013)
GLP-1 medications are best if taken long-term, but shortages, price, and side effects like GI discomfort are potential barriers for some
R Met/Met individuals have higher synaptic dopamine and norepinephrine (because COMT clears them more slowly), which improves prefrontal cortex function and working memory but increases susceptibility to stress-related anxiety, pain sensitivity, and catechol estrogen accumulation
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