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However, several indirect mechanisms may explain why some individuals experience breathing changes whilst taking this medication
Slows intestinal motility
You may also experience more or more intense side effects on tirzepatide
Pushalkar et al., 2018
The company also unveiled a a GLP-1 program offering specialized behavioral support focusing on nutrition and activity for those on GLP-1 medications, such as Ozempic or Mounjaro
Key Takeaways TRIUMPH-4 Phase 3 results (December 2025): 28.7% average body weight loss at 68 weeks on the 12mg dose vs 2.1% on placebo TRIUMPH program scope: Over 5,800 participants across four core trials covering obesity, type 2 diabetes, cardiovascular outcomes, and knee osteoarthritis Additional trials enrolling (April 2026): TRIUMPH-7, -8, and -9 are actively recruiting at Lilly trial sites How to enroll: Search ClinicalTrials.gov for retatrutide or call Lilly at 1-877-CTLILLY Retatrutide is investigational: Not FDA-approved as of April 2026
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