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Hunger selectively modulates corticolimbic activation to food stimuli in humans

[12] [13] It is important to note that patient-reported cognitive symptoms may reflect a nocebo effect, where negative expectations or heightened awareness of potential side effects lead to the perception of symptoms

Moreover GLP-1R agonists (GLP-1RAs) interact with GLP-1R inducing similar effects as that of GLP-1

In this trial, the average HbA1c level dropped by up to 2.1% with a 45 mg dose of orforglipron, while the placebo group showed a decrease of only 0.4%

And how much is speculation