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Additionally, to our knowledge, this is the first network meta-analysis concerning the association between GLP-1 RAs and gastrointestinal adverse events in the population with overweight or obesity, as these evaluations have been predominantly conducted in diabetic patients

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5 Conclusion In conclusion, the expanding body of evidence supports that GLP-1RAs offer a multifaceted approach to ocular therapeutics by targeting key molecular pathways involved in retinal neuroprotection, mitochondrial regulation, inflammation, vascular remodeling, and angiogenesis

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