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Prog Neuropsychopharmacol Biol Psychiatry 46:214223

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Consider: Working with a registered dietitian for personalised nutrition guidance Engaging with structured weight management programmes (available through some NHS services or privately) Addressing psychological factors such as emotional eating, stress management, and sleep quality Setting realistic, achievable goals with regular self-monitoring Patients should be advised that sustainable weight management requires long-term commitment

And the TMD is responsible for further interaction with the N-terminus of the ligand, which triggers receptor activation ( FIGURE 1 GLP-1R is found mainly on the cell membranes of different cell types in the human body

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Cao L, Tang X, Wang X, Wang Y, Dai W