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The red arrows in Figure 1 show what we call long-range interactions, in which substrates allosterically affect distant enzymes in the network
In parallel, the mTORC1 inhibitor rapamycin increased LC3 expression in normal fibroblasts, as assessed by western blotting and immunofluorescence analyses (Fig
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Significantly affected pathways include transforming growth factor-beta (TGF-beta) signaling, with modulation of SMAD-dependent gene transcription
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