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A 2025 meta-analysis found that semaglutide increased the relative risk of cholelithiasis (gallstones) by 1.92 , liraglutide by 1.75 , and tirzepatide by 1.36

10.1371/journal.pone.0027008 PLoS ONE 36 JiangL.LiuX.ChenZ.JinY.HeidbrederC

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