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While the gut-skin axis is an emerging area of research, direct connections between tirzepatide-induced GI effects and skin changes remain speculative and not established in clinical studies

Ferracioli-Oda, E., Qawasmi, A., & Bloch, M

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Yet, the potential neuroprotective effects of triple receptor agonists have been explored in a few preclinical studies [66]

Because semaglutide doesnt affect this enzyme, no interaction is expected

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