rigorous human validation of brain target engagement, salt selection, and risk-benefit evaluation at clinically practical exposures is still required before efficacy claims are warranted
Comfort and Aftercare B12 injections are well tolerated, and a topical anaesthetic is rarely needed for a single deltoid dose, though the same comfort principles apply as with any injectable
Ive been pinning it at 600~ mg a day for a month (mega dosed orally prior), Also on 525 test at the moment but I had to up my calories after starting it
Individuals who have had gastric bypass surgery are also at risk due to alterations to the GI tract that impair the release and absorption of B12
Moreover, N-glycosylation of SREBP cleavage-activating protein (SCAP) is essential for Golgi localization and activation of SREBP once EGFR induced glucose uptake in glioblastoma multiforme (GBM) (Cheng et al., 2015, 2016)
Gastroenterology (2011) 141(5):1696708 e1-2