This isnt just about administering a shot

Guest Episode Womens health and performance: how training, nutrition, and hormones interact across life stages Guest Episode Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards Podcast Episode Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment Guest Episode The science of resistance training, building muscle, and anabolic steroid use in bodybuilding Guest Episode A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions Guest Episode Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use AMA Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent Guest Episode The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods AMA Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins AMA GLP-1 Agonists The Future of Treating Obesity

Acta Pharmaceutica Sinica B, 2021, 11(12): 3889-3907
Mol Biol Evol
These events stimulate the secretion of insulin, helping to compensate for insulin resistance triggered by new-onset diabetes. The drug also suppresses glucagon release by the pancreas, resulting in glucose-dependent reduction in plasma glucose and postprandial glucose by inhibiting hepatic glucose production and delaying gastric emptying. GLP-1s also act in brain regions associated with appetite and reward, reducing food intake and promoting weight loss
To resolve the complex crosstalk among these pathways, machine-learning frameworks built on PANoptosis-related risk scores (PRS) comprised of six key hub genes (YWHAH, PRKACB, PSMB9, FAS, GZMA, and CASP1) have revealed extensive molecular co-activation within tubular and interstitial segments, strongly predicting eGFR decline, serum creatinine elevation, and local immune cell recruitment (209)