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Potential Pro-Cancer Effects: Promoting Tumor Growth: In certain cancers, LL-37 has been found to enhance tumor cell proliferation, migration, and invasion, especially in breast, ovarian, and lung cancers

FOXO4, one of the members of this family, interacts with the p53 protein to help senescent cells avoid apoptosis

Immunological concepts of vaccine adjuvant activity

What the Evidence Actually Supports The 2025 AAOS systematic review (Vasireddi et al.) identified 35 preclinical and only 1 human study meeting inclusion criteria

This extends its effective half-life to approximately 2030 hours and dramatically amplifies its biological activity compared to the native hormone