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However, given that alcohol exposure in animal models increases DNMTs levels some researchers have explored DNMT inhibition as a therapeutic approach against excessive alcohol drinking, finding that 5-aza or decitabine, both DNMT inhibitors, acutely reduce excessive alcohol drinking in rats or mice under certain conditions (Ponomarev et al., 2017

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Heart conditions : Generally safe, but discuss if you have a history of heart failure

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