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Companies with single-source API dependencies for their top revenue products a fact sometimes disclosed in risk factors sections of 10-K filings are particularly exposed

Rijzewijk, L

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Yang B, Shan C, Song X, Lv X, Long Y, Zeng D, et al

Proteases rapidly degrade many peptides, exhibit poor oral bioavailability due to enzymatic breakdown in the digestive tract, and suffer from short systemic half-lives, reducing their clinical efficacy

While these studies involve relatively small groups of participants, their scientific and operational complexity is considerable