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a prespecified analysis confirms benefit is preserved with concomitant SGLT2i use

The blood pressure-lowering effect appears to be driven primarily by weight loss (patients in the STEP trials lost 10-15% of body weight), though improvements in insulin sensitivity and vascular function may also contribute

This prompted significant pushback from wellness entrepreneurs and compounding pharmacies, including litigation alleging that the agency had bypassed legally required notice-and-comment procedures in making those designations

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Presented for research literature review only Azeka E (2005)

Always use fresh, sterile equipment for each reconstitution