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The theoretical rationale is that lower peak concentrations reduce GI side-effect burden
Iliadis S, Papanikolaou NA
Effect of Semaglutide Tablet Formulations: There were no clinically significant differences observed in the mean steady state AUC0-24h,SS and Cmax,SS between the 3 mg, 7 mg and 14 mg doses of RYBELSUS and the 1.5 mg, 4 mg and 9 mg doses of OZEMPIC tablets, respectively, in a clinical study conducted in healthy subjects
Its also simply the drug both doctors are most familiar with
Larazotide: The Zonulin Antagonist Larazotide works by directly targeting zonulin
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