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These medications work by mimicking hormones that control appetite and digestion, potentially aiding in weight loss when combined with diet and exercise

When evaluating effectiveness, injectables seem to be at the top of the list

Metformin, a widely used antidiabetics entering cells through the thiamine transporters, is known to reduce intestinal thiamine content in mice (96)

Adequate protein and micronutrient intake supports energy maintenance

How GLP-1 Agonists Mimic Gut Hormones to Curb Appetite GLP-1 receptor agonists mimic a hormone naturally produced in the gut that signals fullness to the brain and slows digestion

Currently, Madrigal Pharmaceuticals Rezdiffra, approved in 2024, is the only other FDA-cleared treatment for MASH, as reported by Reuters