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The investigation utilized mouse models of chronic stress to track the psychiatric footprint of the weight-loss and diabetes drug liraglutide
DOI: 10.3390/ijms26041651, Wharton, S., Blevins, T., Connery, L., et al
Some studies have shown value of initial metformin-DPP-4 inhibitor combination therapy in special populations
Given that stem cells are core drivers of organismal aging, health and longevity, a greater understanding of these NRF2-based aspects may make it possible one day to rejuvenate tissues in older individuals, thereby increasing human healthspan and perhaps lifespan
Available from: Doshi JA, Li P, Huo H, Pettit AR, Marcus SC
We also show that monotreme GLP-1 stimulates insulin release in cultured rodent islets, but surprisingly shows low receptor affinity and bias toward Erk signaling
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