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Extracellular LDH Activity as a Measurement for Cytotoxicity The release of lactate dehydrogenase (LDH) into culture supernatant correlated with the amount of cell death and membrane damage, providing an accurate measure of cellular toxicity

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They require intention and structure, but not dramatic restriction or extreme measures

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For a 70 kg individual, this translates to approximately 1.75-28 mg per dose, though standard therapeutic protocols use significantly lower daily doses

Several studies have reported pathological astrogliosis and associated neuronal hypotrophic glucose metabolism in patients with neurodegenerative disease and diabetic model animals, showing increased glial fibrillary acidic protein (GFAP) and significant cellular hypertrophy (32), which has been correlated to some extent with the severity of cognitive impairment in patients with Alzheimers disease (AD)