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When that stopped holding, start insulin
It also means reaching clinically meaningful thresholds, like a 10% or 20% reduction, sooner, which translates to earlier improvements in comorbidities like type 2 diabetes, hypertension, and sleep apnea
Twice-daily dosing is used in studies requiring sustained GH elevation or investigating circadian secretion patterns, but is unnecessary for metabolic endpoint studies where once-daily dosing produces equivalent cumulative effects through downstream IGF-1 signaling
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Journal of Clinical Medicine, 12(18), 5921
AACE has indicated in their guidelines that the use of a GLP-1 Analog is indicated first line and when we put the question to our readers, those who had an opinion felt that they were unlikely to recommend GLP-1s as monotherapy
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