In IDH1 mutant glioblastoma, BCAT1 is transcriptionally suppressed because of the hypermethylation of three CpGs in the promoter, and this is also the consequence of IDH1 mutation-induced 2-hydroxyglutarate (2-HG) (Tonjes et al., 2013)
Pickart, Loren, and Anna Margolina
Injection site reactions, including bruising, are documented adverse effects in semaglutide clinical trials, though bruising is not separately reported in FDA labeling
New guidance on the use of GLP-1-based drugs in people with type 1 diabetes (T1D), due to be published later this year, will address the safety and optimal use of these medications which are currently used off-label in this patient population
Cardiovascular and Kidney Protection Both medications offer benefits beyond blood sugar control, which is particularly important for people with diabetes who face increased risks of heart disease and kidney damage
Although it is common to repeat the main analysis on subsets of the randomized population, this is not appropriate when subsets are defined based on post-baseline events