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Both compounds are administered by subcutaneous injection and are peptide-based, which is where their surface-level similarities largely end
At 15 mg, tirzepatide produces the most dramatic weight loss results seen in any GLP-1 medication trial to date, with some patients losing over 25% of their body weight
Dosing frequency GLP-1s vary in their dosing frequency, which can significantly impact patient adherence and preference: Twice-daily: Exenatide (Byetta) Once-daily: Liraglutide (Victoza, Saxenda), Semaglutide tablets (Rybelsus) Once-weekly: Semaglutide (Ozempic, Wegovy), Dulaglutide (Trulicity), Exenatide extended-release (Bydureon), Tirzepatide (Mounjaro, Zepbound) The once-weekly formulations generally offer greater convenience and may improve adherence
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