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However, the development of metabolic disorders, such as dyslipidemia, IR, and hyperglycemia, not only impairs the normal function of the liver, but also triggers a series of complex pathological processes [73]

The comparison between injectable and oral peptides becomes particularly relevant for autoimmune protocols, where consistency of dosing and predictability of effects are essential

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Abbreviations ASCVD: Atherosclerotic cardiovascular disease ATE: Average treatment effect BMI: Body mass index CI: Confidence interval CKD: Chronic kidney disease CV: Cardiovascular eGFR: Estimated glomerular filtration rate GIP: Glucose-dependent insulinotropic polypeptide GLP-1RA: Glucagonlike peptide-1 receptor agonist HBA 1c : Glycated hemoglobin HR: Hazard ratio ICD-10-CM: International Classification of Diseases, Tenth Revision, Clinical Modification MACE: Major adverse cardiovascular event MI: Myocardial infarction OW: Once weekly PY: Person-years RCTs: Randomized controlled trials SGLT2i: Sodium-glucose cotransporter 2 inhibitor SMDs: Standardized mean differences T2D: Type 2 diabetes References Fonseca VA