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Reserpine inhibits VMAT2, preventing vesicular uptake of monoamines and causing depletion of vesicular neurotransmitter stores

Most patients begin noticing early improvements within the first one to two weeks, with the most meaningful results taking shape between weeks four and eight

Concurrently, shifts in GI function/microbiota feedback on the CNS through rapid neurotransmission by the autonomic nervous system and vagus nerve or more slowly through the release of cytokines, pathogen-associated molecular patterns, metabolites, hormones and even neurotransmitters [108]

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Overdosage of some glucocorticoids may result in sodium retention, fluid retention, potassium loss and weight gains