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A candidate for a potential glutathione-scaffold residue was identified using the following selection criteria: The residue should be rather conserved in enzymatically active in contrast to inactive glutaredoxins and have a charged side chain to ensure a strong ionic glutathione interaction (Fig

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants in the body, which can lead to damage to cells and tissues

The initial phase consists of four infusions, and we recommend that it be completed within two weeks

An absent inhibition of human glutaredoxins by S -methylglutathione furthermore suggests that the enzymes react in an encounter reaction 2,19,20

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