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Brucein D, a naturally occurring quassinoid, enhances the sensitivity of pancreatic ductal adenocarcinoma (PDAC) cells to gemcitabine (GEM) by promoting the ubiquitin-proteasome-dependent degradation of NRF2 and suppression of the NRF2 signaling pathway [104]

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Its also unclear if GLP-1 agonists are safe for pregnant or breastfeeding mothers

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Because of the damage doxorubicin does, it creates large numbers of senescent cells