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A once-weekly injection delivering that level of pain relief in patients who may not yet need surgery is a potentially transformative finding
Pharmacokinetic endpoints: if the research objective includes PK characterisation, build in LC-MS quantification of serum peptide at multiple timepoints to generate a concentration-time curve
No pediatric indication or safety data
Challenging for short-term energy levels
Moreover, in in vivo setting, liraglutide promoted M2 macrophage phenotype by the expression of M2 macrophage markers, Arg-1 and CD163, which suggested liraglutide inhibition of atherosclerosis development
Killion recently reported that chronic GIP agonism desensitizes and inhibits the activity of GIPR at least in adipose tissue potentially reconciling the similar body weight directionality observed with agonists and antagonists (69)
