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GLP-1 dosing Your healthcare professional will be able to advise on the appropriate prescription dose of GLP-1s, whether youre: Starting the medication Building up your dose over time Pausing the medication Gradually reducing your dose In general, the medications are first prescribed at the lowest dose, gradually increasing the dose over time

discontinued CJC-1295 (DAC) Not FDA-approved Feature Phase III Trial Data Tesamorelin Yes (n=816 pooled) Sermorelin No adult Phase III VAT datasets CJC-1295 (DAC) No Feature Visceral Fat Reduction Tesamorelin 15-20% at 26 weeks Sermorelin Not formally studied in RCTs CJC-1295 (DAC) Not formally studied in RCTs Feature Liver Fat Reduction Tesamorelin 32% at 12 months (NAFLD trial) Sermorelin Not studied CJC-1295 (DAC) Not studied Feature Typical Research Dose Tesamorelin 2 mg daily Sermorelin 200-300 mcg nightly CJC-1295 (DAC) 1-2 mg weekly Feature Unique Advantage Tesamorelin Only FDA-approved GHRH with deepest trial evidence Sermorelin Longest historical track record CJC-1295 (DAC) Weekly dosing convenience Tesamorelin is the only GHRH peptide with active FDA approval and validated Phase III visceral-fat data

We estimate about 12-15 million patients will be using GLP-1 drugs by 2030 across both indications, which translates to the market growing from ~$30B today to ~$80B by 2030

Potential Benefits of Micro-Dosing GLP-1s: Sustained Appetite Control : Even at lower doses, GLP-1s can continue to help regulate appetite and prevent overeating, making it easier to maintain weight loss over the long term

This transparency is essential for ensuring your safety and the effectiveness of the treatment

I., Orringer, E