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P., Gangadhar, B
denaturation for 10 seconds at 95 C
Finally, 10-formyl-THF can be converted back to THF via the actions of the cytoplasmic ALDH1L1 (aldehyde dehydrogenase 1 family member L1) encoded enzyme
A well-characterized example is ezatiostat (TLK199)a GSH peptidomimetic moleculedesigned to display enhanced cellular uptake and whose metabolites bind the G-site of GSTP1-1 causing enzyme inhibition
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