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Derived from the amino acids lysine and methionine, it plays a fundamental role in cellular function and is particularly concentrated in muscle tissue

Recent studies have revealed that dysregulation of mitochondrial dynamicsincluding impaired mitophagy, imbalances in mitochondrial fusion and fission, and defects in mitochondrial biogenesisis closely associated with CRC initiation, progression, and resistance to therapy [46]

While ROS are a natural byproduct of breathing and metabolism, an imbalancewhere radicals outnumber antioxidantsleads to oxidative stress

Journal of Animal Science

Its varied potential mechanisms are thought to include interaction with inducible and/or endothelial nitric oxide-generating systems, by influencing serotonin, dopamine, GABA, and/or opioid metabolism, and/or by directly aiding blood flow, repair, regrowth, angiogenesis, and remodeling

therefore supplementations with glutathione may be necessary to help ward off oxidative stress as our natural levels decline