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In the TRIUMPH-4 trial, most cases were mild and resolved during ongoing treatment

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In this phase 2a randomized clinical trial of nontreatment-seeking people who smoke, semaglutide monotherapy did not significantly improve laboratory smoking reinstatement or reduce weekly [cigarettes per day] but led to greater reductions in laboratory cigarette intake and reduced weekly nicotine craving, also reducing body weight and HbA1c, wrote Christian S

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The medications are effective for most people