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Beyond its primary location in pancreatic -cells, GLP-1 receptor (GLP-1R) has been identified in various other tissues, including the gastrointestinal tract, lung, kidney, heart, bone, central nervous system, liver, and adipose tissue (Bu et al., 2024)
However, in some situations, the skin reaction may be more severe or persistent
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Cell 166 , 867880 (2016)
Injection-site reactions Like most peptides that are administered via injection, some users have reported mild redness, swelling, or irritation at the injection site
Sources Tirzepatide once weekly for the treatment of obesity
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