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Dosage and How to Take Berberine with Milk Thistle Safely As food supplements rather than licensed medicines, berberine and milk thistle lack standardised dosing recommendations from regulatory authorities such as the MHRA or NICE

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This triggers the phosphorylation and activation of AANAT (arylalkylamine N-acetyltransferase), the rate-limiting enzyme that converts serotonin to N-acetylserotonin