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Once there exists an accumulation of DAMPs, it would trigger the amplification of tissue inflammation, leading to more severe inflammation and CD, forming a vicious circle and disrupting the normal physiological function of tissues and organs (Linkermann et al., 2014

Moreover, stereotaxic lactate injection into the third ventricle induces PD-like phenotypes, including motor impairments, in murine models 8

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It has been of particular interest in research models exploring immune response enhancement, antiviral activity, and immune regulation

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