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Weight Loss Results: What the Data Shows When it comes to shedding pounds, injectable GLP-1s deliver superior results based on extensive clinical trials: Injectable semaglutide (Wegovy ) : 15-17% average body weight loss Injectable tirzepatide (Mounjaro /Zepboun d) : Up to 22.5% average body weight loss FDA-approved oral semaglutide: 13.6-16.6% average body weight loss Compounded ODT formulations : No published clinical trial data available A real-world comparison study found that patients on injectable semaglutide lost 1.62kg more than those on FDA-approved oral semaglutide over 26 weeks, which was not significant
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Its very significant and unprecedented for us in terms of the size and scope, Guerriere said, of the losses
According to clinical trial data from the STEP trials, 43.9% of patients taking semaglutide 2.4 mg experienced nausea at some point during treatment, with the majority of episodes occurring during or immediately after dose increases
A review team from Poland, for example, suggested that future studies should focus on identifying possible side effects
These symptoms typically diminish over several weeks as tolerance develops
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