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Kroner et al (49) demonstrated that elevated iron levels in microglia promote phagocytosis and drive a harmful M1 phenotype, which triggers the release of pro-inflammatory factors such as TNF-, IL-1, IL-6 and nitric oxide (NO), causing neuronal damage

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(PubMed) Leske MC, Wu SY, Hyman L, et al

Consequently, the accumulation of AP sites is mutagenic and will yield cell death

doi: 10.1002/adma.202415818