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The enzyme-catalyzed reverse reaction between GSSG or GSSR and reduced roGFP2 releases roGFP2(SSG) which can instantaneously react via a nonenzymatic shortcut yielding GSH and roGFP2(S 2 ) (Fig

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CD44, the hyaluronic acid receptor, marks cancer stem cells (CSCs) and chemoresistant populations (1040% in TNBC, 7090% in metastatic disease), making HA-conjugated chitosan nanoparticles particularly valuable for eradicating quiescent, self-renewing tumor subpopulations that drive recurrence [125]

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