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NO is synthesized by three types of NO synthase (NOS): endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS ( In contrast, another substrate of DPP-4i, neuropeptide Y1-36 (NPY1-36), has shown potent vasoconstrictive effects

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In many cases, the term microdosing is used loosely and may refer to unsupervised or nonstandard dosing practices rather than medically guided titration

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