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If left untreated, vitamin B12 deficiency can cause neurological changes, such as numbness or tingling in the hands and feet

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On the other hand, trans fatty acids such as elaidic acid (18:1 trans -9) increase the transition temperature of lipid membranes in a similar manner to saturated FFAs such as stearic acid (18:0) and palmitic acid (16:0) (see Figure 4A) [178]

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this represents a significant evidence gap that Phase 3 data will need to address

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