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doi: 10.1038/npp.2011.220 75 HaroonE.MillerA

Previously approved diabetes drugs were weight neutral or caused weight gain, a concern because obesity is often a co-morbidity of T2DM and can increase the risk for a cardiovascular complication, such as a heart attack or stroke

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Inflammatory Cytokines and Sexual Desire CRP and IL-6, both elevated in obesity, directly suppress hypothalamic GnRH secretion and reduce androgen receptor sensitivity